Master Control Genes in Development and Evolution: The Homeobox Story (The Terry Lectures Series)


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And he illustrates the universality of the genetic control of development by describing the development of the eye; eyes as different as those of humans, squids, and flies, he shows, develop under the same master control gene. Gehring is professor in the department of cell biology at the University of Basel, Switzerland. He recently shared the March of Dimes Prize for research in developmental biology. In the absence of Gdnf, ureteric bud formation is not initiated. Molecular analysis of this phenotype demonstrates that Hox 11 control of early metanephric induction is accomplished by the interaction of Hox 11 genes with the pax-eya-six regulatory cascade, a pathway that may be used by Hox genes more generally for the induction of multiple structures along the anteroposterior axis.

Deregulated HOX genes in ameloblastomas are located in physical contiguity to keratin genes. The expression of the HOX gene network in mid-stage human tooth development mostly concerns the epithelial tooth germ compartment and involves the C and D HOX loci. To further dissect the HOX gene implication with tooth epithelium differentiation we compared the expression of the whole HOX network in human ameloblastomas, as paradigm of epithelial odontogenic tumors, with tooth germs.

EMBL - European Molecular Biology Laboratory

We identified two ameloblastoma molecular types with respectively low and high number of active HOX C genes. The highly expressing HOX C gene ameloblastomas were characterized by a strong keratinized phenotype. Locus C HOX genes are located on chromosome 12q in physical contiguity with one of the two keratin gene clusters included in the human genome. Inside the HOX C locus, a 2.


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Interestingly both loci are deregulated in ameloblastomas. Our finding support an important role of the HOX network in characterizing the epithelial tooth compartment. Furthermore, the physical contiguity between locus C HOX and keratin genes in normal tooth epithelium and their deregulation in the neoplastic counterparts suggest they may act on the same mechanism potentially involved with epithelial tumorigenesis. Tbx16 regulates hox gene activation in mesodermal progenitor cells. Mesodermal progenitor cells MPCs fail to differentiate into trunk somites in tbx16 mutants and instead accumulate within the tailbud in an immature state.

The mechanisms by which Tbx16 controls mesoderm patterning have remained enigmatic, and we describe here the application of photoactivatable morpholino oligonucleotides to determine the Tbx16 transcriptome in MPCs.

We identify Tbxregulated genes that are expressed in zebrafish gastrulae, including several developmental signaling proteins and regulators of gastrulation, myogenesis, and somitogenesis. Unexpectedly, we observe that loss of Tbx16 function precociously activates posterior hox genes in MPCs, and overexpression of a single posterior hox gene is sufficient to disrupt MPC migration. Our studies support a model in which Tbx16 regulates the timing of collinear hox gene activation to coordinate the anterior-posterior fates and positions of paraxial MPCs.

Butterfly eyespot serial homology: enter the Hox genes. Hox genes modify serial homology patterns in many organisms, exemplified in vertebrates by modification of the axial skeleton and in arthropods by diversification of the body segments. Butterfly wing eyespots also appear in a serial homologous pattern that, in certain species, is subject to local modification. A paper in EvoDevo reports the Hox gene Antp is the earliest known gene to have eyespot-specific expression; however, not all Lepidoptera express Antp in eyespots, suggesting some developmental flexibility.

Homeosis and beyond. What is the function of the Hox genes? At first glance, it is a curious question. What these authors meant is that these genes have lost their 'homeotic' function. Indeed, 'homeotic' refers to a functional property that is so often associated with the Hox genes. However, the word ' Hox ' should not be used to refer to a function, but to a group of genes. Reversely, many genes , not belonging to the Hox group, do present a homeotic function. In the present chapter, I will first give a definition of the Hox genes.

I will then ask what is the 'function' of a gene , examining its various meanings at different levels of biological organization. I will review and revisit the relation between the Hox genes and homeosis. I will suggest that their morphological homeotic function has been secondarily derived during the evolution of the Bilateria. Intact cluster and chordate-like expression of Para Hox genes in a sea star.

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Background The Para Hox genes are thought to be major players in patterning the gut of several bilaterian taxa. Though this is a fundamental role that these transcription factors play, their activities are not limited to the endoderm and extend to both ectodermal and mesodermal tissues. In some taxa mostly chordates but to some degree also in protostomes the three genes are arranged into a genomic cluster, in a similar fashion to what has been shown for the better-known Hox genes.

Sea urchins possess the full complement of Para Hox genes but they are all dispersed throughout the genome, an arrangement that, perhaps, represented the primitive condition for all echinoderms. In order to understand the evolutionary history of this group of genes we cloned and characterized all Para Hox genes , studied their expression patterns and identified their genomic loci in a member of an earlier branching group of echinoderms, the asteroid Patiria miniata.

Seminars - EMBL

Results We identified the three Para Hox orthologs in the genome of P. While one of them, PmGsx is provided as maternal message, with no zygotic activation afterwards, the other two, PmLox and PmCdx are expressed during embryogenesis, within restricted domains of both endoderm and ectoderm. Screening of a Patiria bacterial artificial chromosome BAC library led to the identification of a clone containing the three genes. Conclusions The identification of P. Since the presence of an intact cluster, or at least a partial cluster, has been reported in chordates and polychaetes respectively, it becomes clear that within echinoderms, sea urchins have modified the original bilaterian arrangement.

Moreover, the sea star.

Ebook Master Control Genes in Development and Evolution: The Homeobox Story (The Terry Lectures

Summary The neural circuits governing vital behaviors, such as respiration and locomotion, are comprised of discrete neuronal populations residing within the brainstem and spinal cord. Work over the past decade has provided a fairly comprehensive understanding of the developmental pathways that determine the identity of major neuronal classes within the neural tube. However, the steps through which neurons acquire the subtype diversities necessary for their incorporation into a particular circuit are still poorly defined.

Studies on the specification of motor neurons indicate that the large family of Hox transcription factors has a key role in generating the subtypes required for selective muscle innervation.

The Evolution of Hox Genes

There is also emerging evidence that Hox genes function in multiple neuronal classes to shape synaptic specificity during development, suggesting a broader role in circuit assembly. This review highlights the functions and mechanisms of Hox gene networks, and their multifaceted roles during neuronal specification and connectivity. Visual demonstrations of abstract scientific concepts are effective strategies for enhancing content retention Shmaefsky The concepts associated with gene regulation of growth and development are particularly complex and are well suited for teaching with visual models.

This demonstration provides a simple and accurate model of Hox gene…. Are Hox genes ancestrally involved in axial patterning? Evidence from the hydrozoan Clytia hemisphaerica Cnidaria. The early evolution and diversification of Hox -related genes in eumetazoans has been the subject of conflicting hypotheses concerning the evolutionary conservation of their role in axial patterning and the pre-bilaterian origin of the Hox and Para Hox clusters.

However, the existence of a " Hox code" predating the cnidarian-bilaterian ancestor and supporting the deep homology of axes is more controversial. Hox , Para Hox and Hox -related genes have been investigated here by phylogenetic analysis and in situ hybridisation in Clytia hemisphaerica, an hydrozoan species with medusa and polyp stages alternating in the life cycle. Cross species comparison reveals a strong variability of gene expression along the oral-aboral axis and during the life cycle among cnidarian lineages.

Calcisponges have a Para Hox gene and dynamic expression of dispersed NK homeobox genes. Sponges are simple animals with few cell types, but their genomes paradoxically contain a wide variety of developmental transcription factors, including homeobox genes belonging to the Antennapedia ANTP class, which in bilaterians encompass Hox , Para Hox and NK genes.


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  4. In the genome of the demosponge Amphimedon queenslandica, no Hox or Para Hox genes are present, but NK genes are linked in a tight cluster similar to the NK clusters of bilaterians. It has been proposed that Hox and Para Hox genes originated from NK cluster genes after divergence of sponges from the lineage leading to cnidarians and bilaterians. On the other hand, synteny analysis lends support to the notion that the absence of Hox and Para Hox genes in Amphimedon is a result of secondary loss the ghost locus hypothesis.

    Here we analysed complete suites of ANTP-class homeoboxes in two calcareous sponges, Sycon ciliatum and Leucosolenia complicata. Our phylogenetic analyses demonstrate that these calcisponges possess orthologues of bilaterian NK genes Hex, Hmx and Msx , a varying number of additional NK genes and one Para Hox gene , Cdx. Despite the generation of scaffolds spanning multiple genes , we find no evidence of clustering of Sycon NK genes. All Sycon ANTP-class genes are developmentally expressed, with patterns suggesting their involvement in cell type specification in embryos and adults, metamorphosis and body plan patterning.

    These results demonstrate that Para Hox genes predate the origin of sponges, thus confirming the ghost locus hypothesis, and highlight the need to analyse the genomes of multiple sponge lineages to obtain a complete picture of the ancestral composition of the first animal genome.

    Master Control Genes in Development and Evolution: The Homeobox Story (The Terry Lectures Series) Master Control Genes in Development and Evolution: The Homeobox Story (The Terry Lectures Series)
    Master Control Genes in Development and Evolution: The Homeobox Story (The Terry Lectures Series) Master Control Genes in Development and Evolution: The Homeobox Story (The Terry Lectures Series)
    Master Control Genes in Development and Evolution: The Homeobox Story (The Terry Lectures Series) Master Control Genes in Development and Evolution: The Homeobox Story (The Terry Lectures Series)
    Master Control Genes in Development and Evolution: The Homeobox Story (The Terry Lectures Series) Master Control Genes in Development and Evolution: The Homeobox Story (The Terry Lectures Series)
    Master Control Genes in Development and Evolution: The Homeobox Story (The Terry Lectures Series) Master Control Genes in Development and Evolution: The Homeobox Story (The Terry Lectures Series)
    Master Control Genes in Development and Evolution: The Homeobox Story (The Terry Lectures Series) Master Control Genes in Development and Evolution: The Homeobox Story (The Terry Lectures Series)

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